Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma

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Presentation transcript:

Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma Leonie S van Rijt, MSc, Nanda Vos, BSc, Monique Willart, BSc, Alex KleinJan, PhD, Anthony J Coyle, PhD, Henk C Hoogsteden, MD, PhD, Bart N Lambrecht, MD, PhD Journal of Allergy and Clinical Immunology Volume 114, Issue 1, Pages 166-173 (July 2004) DOI: 10.1016/j.jaci.2004.03.044

Fig 1 Proliferation and TH2 differentiation of naive T cells induced by means of sensitization with CD80/CD86−/− DCs compared with WT DCs. The number of induced divisions in adoptively transferred CFSE+/OVA TCR Tg/CD4+ T cells in mice were sensitized with either OVA-pulsed WT DCs (A; left panel) or OVA-pulsed CD80/CD86−/− DCs (A; middle panel) or unpulsed DCs (A; right panel) is shown. UNP, Unpulsed. B, TH2 cytokine production by lung-draining LN cells (∗P<.05 in comparison with CD80/86−/− DCs). Journal of Allergy and Clinical Immunology 2004 114, 166-173DOI: (10.1016/j.jaci.2004.03.044)

Fig 2 No induction of eosinophilic airway inflammation in response to inhaled allergen in CD80/CD86−/− DC–sensitized mice. Mice were sensitized with OVA-pulsed WT DCs (OVA WT), OVA-pulsed CD80/CD86−/− DCs (OVA KO), or unpulsed WT DCs (PBS WT) and were challenged with OVA aerosols. Total cell numbers (A) and numbers of eosinophils (Eos; B) in BALF were determined (∗P<.05 in comparison with OVA-pulsed WT DCs). C, TH2 cytokine production by draining LN cells of the lung (∗P<.05). Sections of lungs from OVA aerosol–challenged mice sensitized with OVA-pulsed WT DCs (D), OVA-pulsed CD80/CD86−/− DCs (E), and PBS-pulsed WT DCs (F). Lungs were stained with periodic acid–Schiff. Journal of Allergy and Clinical Immunology 2004 114, 166-173DOI: (10.1016/j.jaci.2004.03.044)

Fig 3 Induction of eosinophilic airway inflammation in response to challenge with CD80/CD86−/− DCs in WT DC–sensitized mice. Mice were sensitized with OVA-pulsed WT DCs and challenged with either OVA-pulsed CD80/CD86−/− DCs (WT/KO) or OVA-pulsed WT DCs (WT/WT). A, Total cell numbers and number of eosinophils in BALF were determined. B, TH2 cytokine production by lung-draining LN cells (∗P<.05). Sections of lungs from WT-DC–sensitized mice challenged with OVA-pulsed CD80/CD86−/− DCs (C) or OVA-pulsed WT DCs (D). Lungs were stained with hematoxylin and eosin. E, C57Bl/6 mice were sensitized with OVA-pulsed WT DCs and challenged with either an intratracheal injection of OVA-pulsed CD80/CD86−/− DCs (WT/KO), CD80/CD86−/− DCs in combination with α-ICOS (WT/KO+α-ICOS), or WT DCs (WT/WT). Total cell numbers and numbers of eosinophils in BALF were determined. Journal of Allergy and Clinical Immunology 2004 114, 166-173DOI: (10.1016/j.jaci.2004.03.044)