Eric Dai MD, Pawan Prasher MD, James McCulley MD, R. Wayne Bowman MD.

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Presentation transcript:

Eric Dai MD, Pawan Prasher MD, James McCulley MD, R. Wayne Bowman MD. Corneal Densitometry Measurement After Deep Anterior Lamellar Keratoplasty by Oculus Pentacam Eric Dai MD, Pawan Prasher MD, James McCulley MD, R. Wayne Bowman MD. The University of Texas Southwestern Medical Center, Dallas, TX.

Commercial Support Disclosure The authors do not have any financial arrangements or affiliations regarding the products and technology used in this study.

Purpose To correlate changes in corneal densitometry values from Oculus Pentacam with clinical slit lamp examination after deep anterior lamellar keratoplasty (DALK).

Methods Pentacam images and slit lamp photographs were performed in nine eyes of nine patients at various intervals during the postoperative course after DALK. Nine eyes of nine patients with no prior corneal surgery served as controls. The values for peak anterior stromal density and posterior stromal density at the level of the graft interface along the 180 degree axis were chosen for analysis. These values were subsequently correlated with clinical grading of interface haze using previously published guidelines1.

Clinical Grading of Interface Haze1 Grade 0 for a completely clear cornea Grade 0.5 for trace haze seen with careful oblique illumination with slit-lamp biomicroscopy Grade 1 for more prominent haze not interfering with visibility of fine iris details Grade 2 for mild obscuration of iris details Grade 3 for moderate obscuration of the iris and lens Grade 4 for completely opacification of the stroma

Results – Control Group Pentacam Values Patient Number Anterior Corneal Densitometry Value Posterior Corneal 1 31.4 23.4 2 24.3 21.2 3 26 20.2 4 25.3 18 5 24.5 19.5 6 30.7 18.2 7 29.4 20 8 25.4 19.8 9 24.8 18.1

Results – Study Population Patient No. Age Operated Eye Duration from surgery to Pentacam Exam (days) Anterior Corneal Densitometry Value Posterior Slit Lamp Interface Haze Grade 1 39 OD 146 35.7 42.7 3 2 41 OS 117 52.9 27.6 0.5 33 87 39.2 23.6 4 20 253 38.3 69.2 5 25 143 40.8 66.3 6 40 13 68.7 34.1 7 64 34 58.5 45.7 8 28 216 34.5 27.1 9 76 57.8

Results Study Group Mean Standard Deviation Average Post Op Duration (Days) 121 79 Average Anterior Densitometry 47 12 Anterior Densitometry Range 34.5 to 68.7 Average Posterior Densitometry 41 17 Posterior Densitometry Range 23.6 to 69.2 Control Group Mean Standard Deviation Average Anterior Densitometry 27 3 Anterior Densitometry Range 24.3 to 31.4 Average Posterior Densitometry 20 2 Posterior Densitometry Range 18 to 23.4

Results On slit lamp examination, interface haze varied from grade 0.5 to 3 in the study group. Both anterior and posterior stromal densitometry values in the DALK patients were significantly greater than in the control group (p<0.01).

Patient No. 2 – Grade 0.5 Haze

Patient No. 2 – Grade 0.5 Haze

Patient No. 9– Grade 2 Haze

Patient No. 9– Grade 2 Haze

Patient No. 1 – Grade 3 Haze

Patient No. 1 – Grade 3 Haze

Conclusion Corneal densitometry values obtained by the Oculus Pentacam were signifcantly higher in patients with interface haze after DALK. Corneal densitometry appears to correlate with subjective assessment of corneal interface haze by clinical slit lamp examination in patients undergoing DALK. The Pentacam may be a useful tool to quantify interface haze in the post operative course of DALK. Additional study in a larger patient population is needed to further evaluate the utility of the Pentacam in grading interface haze.

References Fantes FE, et. al. Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys. Arch Ophthalmol. 1990 May;108(5):665-75.