Focus on endometrial and cervical cancer

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Focus on endometrial and cervical cancer Lora Hedrick Ellenson, T.-C Wu Cancer Cell Volume 5, Issue 6, Pages 533-538 (June 2004) DOI: 10.1016/j.ccr.2004.05.029

Figure 1 Histological and molecular characteristics of endometrial lesions The precursor lesions are shown on the left and the invasive tumors on the right. The common molecular genetic alterations found in each morphologic entity are shown directly below each photomicograph. SH, simple hyperplasia; CH, complex hyperplasia; CAH, complex atypical hyperplasia; G1, Grade 1 endometrioid carcinoma; G2, Grade 2 endometrioid carcinoma; G3, Grade 3 endometrioid carcinoma; EIC, endometrial intraepithelial carcinoma; USC, papillary form of serous carcinoma; USC glandular, glandular form of serous carcinoma. Cancer Cell 2004 5, 533-538DOI: (10.1016/j.ccr.2004.05.029)

Figure 2 HPV-infected malignant cells displaying upregulated p16INK4A Staining was performed on consecutive sections. A: H&E stain of a lesion biopsied from a patient with squamous cell carcinoma of the cervix. The biopsy shows an area of malignant tumor cells separated from benign squamous epithelium by a region of normal stromal tissue. The tumor cells show abnormal squamous differentiation. B: Immunohistochemical stain for p16INK4A. p16-positive areas stained brown within the tumor. C: HPV in situ hybridization. Presence of HPV-16 genomes was indicated by a brown, speckled pattern within the nuclei of tumor cells. Cancer Cell 2004 5, 533-538DOI: (10.1016/j.ccr.2004.05.029)