Seizure - European Journal of Epilepsy Successful treatment of super-refractory tonic status epilepticus with rufinamide: First clinical report  A.G.B. Thompson, H.R. Cock  Seizure - European Journal of Epilepsy  Volume 39, Pages 1-4 (July 2016) DOI: 10.1016/j.seizure.2016.04.003 Copyright © 2016 British Epilepsy Association Terms and Conditions

Fig. 1 Electroencephalography (EEG). (A) Ictal EEG. Tonic seizure starts at the purple line. Fast rhythmical activity (21Hz) precedes clinical onset, followed by slow activity (2.5–4Hz) with anterior emphasis. (B) Inter-ictal EEG 1. Mild excess of slow wave activity with intermittent irregular temporal theta. (C) Inter-ictal EEG 2. Excess of slow wave activity in background. Fairly frequent bursts of spikes/polyspikes and slow wave complexes, without clinical accompaniment. Seizure - European Journal of Epilepsy 2016 39, 1-4DOI: (10.1016/j.seizure.2016.04.003) Copyright © 2016 British Epilepsy Association Terms and Conditions

Fig. 2 Summary of anti-epileptic drug doses and seizure burden over the first 60 days of admission. For general anaesthesia, bars at “100%” indicate maintenance of anaesthesia aiming for clinical seizure freedom, bars at “50%” indicate a period of attempted weaning of anaesthesia. The daily seizure burden was calculated from bedside nursing seizure charts recording the number and duration of individual seizures. Seizure - European Journal of Epilepsy 2016 39, 1-4DOI: (10.1016/j.seizure.2016.04.003) Copyright © 2016 British Epilepsy Association Terms and Conditions