Figure 5 MRI of childhood craniopharyngioma

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Long-term follow up of patients with craniopharyngioma

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--- 6-months’ therapy months’ therapy Supplementary Figure 1.

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Figure 5 MRI of childhood craniopharyngioma Figure 5 | MRI of childhood craniopharyngioma. MRI at diagnosis and 36 months after surgery in three cases of childhood craniopharyngioma with different grades of hypothalamic involvement and/or lesion are shown. Patient with craniopharyngioma confined to the intrasellar space: grade 0 hypothalamic involvement (part a); surgical lesion (part b). BMI at diagnosis: −1.96 SD; BMI 36 months after complete resection: −1.62 SD. Patient with craniopharyngioma involving the anterior hypothalamus: grade 1 hypothalamic involvement (part c); surgical lesion of the anterior hypothalamic area (part d). BMI at diagnosis: +1.01 SD; BMI 36 months after complete resection: +0.59 SD. Patient with craniopharyngioma involving the anterior and posterior hypothalamus: grade 2 hypothalamic involvement (part e); surgical lesion of the anterior and posterior hypothalamic area (part f). BMI at diagnosis: +6.08 SD; BMI 36 months after complete resection: +6.79 SD. Mammillary bodies define the border between anterior and posterior involvement and/or lesion. Part e and part f are adapted from Müller, H. L. et al., Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur. J. Endocrinol., 165 (1), 17–24 (2011), BioScientifica. Parts e and f are adapted from Müller, H. L. et al. Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3‑year follow‑up. Eur. J. Endocrinol. 165 (1), 17–24 (2011), BioScientifica Müller, H. L. et al. (2017) New outlook on the diagnosis, treatment and follow‑up of childhood-onset craniopharyngioma Nat. Rev. Endocrinol. doi:10.1038/nrendo.2016.217