Richard G Lea: consortium representation

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Presentation transcript:

Richard G Lea: consortium representation University of Nottingham Higher Education Academic Institution, UK School of Veterinary Medicine and Science & School of Biosciences Speciality of University Campus: REPRODUCTION Richard.Lea@nottingham.ac.uk http://www.nottingham.ac.uk/

Proposal Objectives: Environmental chemical mixtures: health disease associations (Human studies) Human fetal liver and placenta EDC burdens and profiling miRNA biomarkers. IVF embryos & gamete exposome: developmental consequences

Proposal Objectives: Environmental chemical mixtures: health disease associations (Animal models) EDC burden of meat - sewage sludge model – human exposure (exposome) Dog sentinel species: consumption of meat and sharing environment. Fetal, neonatal & adult. Biomarkers in sheep and dog models Susceptibility: cohort of sludge exposed animals with and without testis abnormalities (Biomarkers)

The partnership: Existing network Skills Requirements REEF FP7 & clustered DEER and CONTAMED Skills Access to unique human fetal tissue. Chemical measurement Animal models – sheep, dog Histology, omics technologies & next generation sequencing Requirements Epidemiologist Clinical input

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