Friedel–Crafts reaction

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Presentation transcript:

Friedel–Crafts reaction

What is the reaction? Formation of C–C bond to aromatic ring Two types C–C bond forms Alkylation substitution with R e.g. CH3Cl Acylation substitution with R–CO e.g. CH3COCl

Alkylation Reagents and conditions Alkyl chloride, RCl Halogen carrier catalyst, e.g. AlCl3 Anhydrous conditions

Examples of alkylation Substitution with CH3Cl Substitution with C2H5Cl C–C bond forms

Acylation Reagents and conditions Alkyl chloride, RCOCl Halogen carrier catalyst, e.g. AlCl3 Anhydrous conditions

Examples of acylation Substitution with CH3COCl Substitution with C2H5COCI C–C bond forms