Cg-OxyR disulfide formation reorganizes its tetrameric conformation.

Slides:

Advertisements

Similar presentations

Volume 18, Issue 2, Pages (February 2010)

Advertisements

Comparison (θ) of the mean dinucleotide variability distribution for (A) genes with MAE vs. Comparison (θ) of the mean dinucleotide variability distribution.

Comparison (R) of the mean observed to expected dinucleotide distribution for (A) genes with MAE vs. Comparison (R) of the mean observed to expected dinucleotide.

Distribution of mutations in different groups of genes, in cancer with extreme ML values. Distribution of mutations in different groups of genes, in cancer.

Empirical mutation-selection phase diagram of tumor evolution.

Comparison of Cg-OxyR active-site pocket with previously published structures. Comparison of Cg-OxyR active-site pocket with previously published structures.

Cg-OxyR crystal structure shows a more symmetric subunit arrangement compared with the asymmetric relation between the RD and DBD homodimers of Pa-OxyR.

New archeological excavations in San Marcos cave.

Evolutionary relationships between ancient Tehuacán maize and its wild or cultivated relatives. Evolutionary relationships between ancient Tehuacán maize.

ERVmap reveals additional breast cancer-associated ERVs that correlate with cytolytic activity. ERVmap reveals additional breast cancer-associated ERVs.

Cg-OxyR controls catalase transcription, recovery from lag phase, survival to H2O2 stress, and H2O2 scavenging rate. Cg-OxyR controls catalase transcription,

Two functional states of human CFTR

Genomic evidence of partial domestication in ancient Tehuacán maize.

Cg-OxyR oxidation decreases binding affinity and extension to the catalase promoter region. Cg-OxyR oxidation decreases binding affinity and extension.

C206, T107, and R278 are the crucial residues for H2O2 catalysis.

Pretreatment of VSV-GPΔ to form VSV-GP19K rescues infection in the α5β1-integrin-negative CHO cells. Pretreatment of VSV-GPΔ to form VSV-GP19K rescues.

Fundamental epidemiological indicators.

Cg-OxyR shows rapid conformational changes upon oxidation.

Energy diagrams and orientation distributions of the NO molecule.

Structure-based ligand design toward a selective M3R antagonist.

Social activity of humans and bots over time.

Immunity-related genes and enhancers are enriched for eQTLs.

Stereoview of the structural superposition of IspH protein from E

Patients with SLE have elevated ERV expression.

Estimation of R(t). Estimation of R(t). (A) Daily R(t) as inferred from the daily incidence of new infections for one stochastic model realization. Tg.

Proposed reaction sequence initiating HMBPP reduction as it was derived from crystallographic data. Proposed reaction sequence initiating HMBPP reduction.

Volume 9, Issue 2, Pages (February 2002)

A Fence-like Coat for the Nuclear Pore Membrane

Transcriptional response to mating in whole A. gambiae females.

Structures of natural cytotoxicity receptors.

Light-activated RPS6 phosphorylation depends on auxin but not photosynthesis or exogenous glucose. Light-activated RPS6 phosphorylation depends on auxin.

Volume 11, Issue 6, Pages (June 2003)

Structural overview. Structural overview. (A) Domain organization of LRRK2. The residue boundary of the WD40 domain and locations of three recurrent disease.

Volume 22, Issue 1, Pages (January 2014)

Volume 18, Issue 2, Pages (February 2010)

Solution and Crystal Structures of a Sugar Binding Site Mutant of Cyanovirin-N: No Evidence of Domain Swapping Elena Matei, William Furey, Angela M.

Site-specific recombination in plane view

Volume 22, Issue 6, Pages (June 2014)

Multiple Conformations of F-actin

Volume 11, Issue 6, Pages (June 2003)

Volume 124, Issue 5, Pages (March 2006)

Zhenjian Cai, Nabil H. Chehab, Nikola P. Pavletich Molecular Cell

André Schiefner, Michaela Gebauer, Antonia Richter, Arne Skerra

Volume 24, Issue 7, Pages (July 2016)

Structures of Two Repeats of Spectrin Suggest Models of Flexibility

Myosin structure: Does the tail wag the dog?

Volume 74, Issue 5, Pages (May 1998)

Volume 11, Issue 2, Pages (February 2003)

Volume 11, Issue 4, Pages (April 2003)

Crystal Structure of the Human Myeloid Cell Activating Receptor TREM-1

Lymphocyte lineage trees produced by long-term live cell microscopy.

Clustering of residues for which PREs unaccounted for by the main state were measured. Clustering of residues for which PREs unaccounted for by the main.

Crystal structure of STAT6CF-N3 complex and its comparison with STAT6CF-N4 complex structure. Crystal structure of STAT6CF-N3 complex and its comparison.

Schematic representation of our random walk model with environmental state-dependent dynamics. Schematic representation of our random walk model with environmental.

Volume 24, Issue 7, Pages (July 2016)

Coupling to heterotrimers with C-terminal Gα subunit chimeras.

(A–F) FRET provides evidence for compaction.

(A) X-ray diffraction powder pattern of (Top) SAC (solvent-assisted crystallized), (Middle) LG, and (Bottom) SG diF-TEG ADT spin-coated films at 153 K.

Details of the Toll–Spätzle interaction.

Volume 87, Issue 7, Pages (December 1996)

Clemens C. Heikaus, Jayvardhan Pandit, Rachel E. Klevit Structure

Fraction of BaP remaining in an 8-nm-thick cooking oil film exposed to different gas-phase ozone mixing ratios after 1 h (black), 12 h (purple), 1 d (blue),

Amanda Nga-Sze Mak, Abigail R. Lambert, Barry L. Stoddard Structure

Pingwei Li, Gerry McDermott, Roland K. Strong Immunity

Volume 14, Issue 3, Pages (March 2006)

Volume 100, Issue 3, Pages (February 2000)

Temporal behavior of mismatch between fully renewable electricity production and demand in Switzerland throughout the year for the urban scenario (red)

Fig. 6 Structural basis for the constitutive activity of US28.

The primary axis scores of each sample from a constrained ordination of principal coordinates (CAP) for the temperature profile of each city are indicated.

Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle Daniel R. Southworth, David A. Agard Molecular.

Presentation transcript:

Cg-OxyR disulfide formation reorganizes its tetrameric conformation. Cg-OxyR disulfide formation reorganizes its tetrameric conformation. (A) Crystal structure of reduced tetrameric Cg-OxyRC206S and a close-up view of the S206 and C215 of a single protomer (Right). (B) Crystal structure of the disulfide tetrameric Cg-OxyRSS, generated by crystallographic symmetry, with a close-up of the disulfide-bonded C206-C215 of a single protomer (Right). For both structures, each protomer is colored separately, and the RD homodimer formed by the blue and light-blue protomers were aligned before figure preparation, thereby providing a common orientation for structural comparison. (C) Each panel is a focused view of the relative positions of S206/C206 and C215 of the three crystal structures reported in this study. A structural alignment of all three structures was performed to provide a common orientation. The Left panel depicts the S206 and C215 of Cg-OxyRC206S, and is equivalent to the fully folded state of Cg-OxyRH2O2. The Center panel shows the locally unfolded state of Cg-OxyRH2O2, and the Right panel shows the C206-C215 disulfide of Cg-OxyRSS. Brandán Pedre et al. PNAS doi:10.1073/pnas.1807954115 ©2018 by National Academy of Sciences