Regenerative Medicine and the Gut

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Regenerative Medicine and the Gut Johann Peterson, Pankaj J. Pasricha Gastroenterology Volume 141, Issue 4, Pages 1162-1166.e2 (October 2011) DOI: 10.1053/j.gastro.2011.08.010 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Schema for lung tissue engineering. (A) Native adult rat lung is cannulated in the pulmonary artery and trachea for infusion of decellularization solutions. (B) Cellular lung matrix is devoid of cells after 2–3 hours of treatment. (C) Acellular matrix is mounted inside a biomimetic bioreactor that allows seeding of vascular endothelium into the pulmonary artery and pulmonary epithelium into the trachea. (D) After 4–8 days of culture, the engineered lung is removed from the bioreactor and is suitable for implantation into (E) the syngeneic rat recipient.36 From Petersen TH, et al. Tissue-engineered lungs for in vivo implantation. Science 2010;329(5991):538–541. Reprinted with permission from the AAAS. Gastroenterology 2011 141, 1162-1166.e2DOI: (10.1053/j.gastro.2011.08.010) Copyright © 2011 AGA Institute Terms and Conditions