Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine–induced injury in human internal thoracic.

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Presentation transcript:

Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine–induced injury in human internal thoracic artery Chao Xuan, MPhil, Feng-Jun Chang, MD, Xiao-Cheng Liu, MD, Xiao-Yan Bai, MD, Xiao-Long Liao, MD, Guo-Wei He, MD, PhD, DSc, Jing-Song Ou, MD, PhD, FCCP The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 3, Pages 697-703 (September 2012) DOI: 10.1016/j.jtcvs.2012.01.020 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Mean concentration (log M)–relaxation (percentage reversal of U46619-induced contraction) curves for acetylcholine (ACh) of left internal thoracic artery rings with endothelium (E+, n = 8) or without endothelium (E−, n = 4). B, Mean concentration–relaxation curves for acetylcholine (ACh) of left internal thoracic artery rings (n = 8 in each group) in the absence or presence of asymmetric dimethylarginine (ADMA) or asymmetric dimethylarginine with AVE3085 (ADMA+AVE). Rings with endothelium were regarded as control. Values are expressed as mean ± SEM. Asterisk indicates P < .001 versus control group; dagger indicates P < .05 versus asymmetric dimethylarginine group; 2-way analysis of variance. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 697-703DOI: (10.1016/j.jtcvs.2012.01.020) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Mean concentration (log M)–relaxation (percentage reversal of U46619-induced contraction) curves for acetylcholine (ACh) in the left internal thoracic artery rings (n = 8 in each group) in the absence or presence of asymmetric dimethylarginine (ADMA) or asymmetric dimethylarginine with dimethyl sulfoxide (ADMA+DMSO). Data are shown as mean ± SEM. Asterisk indicates P < .001 versus control group by 2-way analysis of variance. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 697-703DOI: (10.1016/j.jtcvs.2012.01.020) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Protein expression of endothelial nitric oxide synthase (eNOS) in human left internal thoracic artery rings. Arterial rings were incubated with asymmetric dimethylarginine (ADMA) in Krebs solution with or without the addition of AVE3085 (AVE) or for the same period in Krebs solution alone (control). Date are shown as mean ± SEM. Asterisk indicates P < .05 versus control group; hatch mark indicates P < .05 versus asymmetric dimethylarginine group; n = 8, 1-way analysis of variance. GAPDH, Glyceraldehyde 3-phosphate dehydrogenase. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 697-703DOI: (10.1016/j.jtcvs.2012.01.020) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Superoxide production in human left internal thoracic artery rings. Vascular rings were incubated with asymmetric dimethylarginine (ADMA, 100 μmol/L) in Krebs solution with or without the addition of AVE3085 (AVE, 30 μmol/L) or in Krebs solution alone (control). Data are shown as mean ± SEM. Asterisk indicates P < .05 versus control group; hatch mark indicates P < .05 versus asymmetric dimethylarginine group; n = 7; 1-way analysis of variance. RLU, Relative light units. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 697-703DOI: (10.1016/j.jtcvs.2012.01.020) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions