High-Dose Infusional Gemcitabine Combined with Busulfan and Melphalan with Autologous Stem-Cell Transplantation in Patients with Refractory Lymphoid.

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Presentation transcript:

High-Dose Infusional Gemcitabine Combined with Busulfan and Melphalan with Autologous Stem-Cell Transplantation in Patients with Refractory Lymphoid Malignancies Yago Nieto, Peter Thall, Ben Valdez, Borje Andersson, Uday Popat, Paolo Anderlini, Elizabeth J. Shpall, Roland Bassett, Amin Alousi, Chitra Hosing, Partow Kebriaei, Muzaffar Qazilbash, Erin Frazier, Alison Gulbis, Christina Chancoco, Qaiser Bashir, Stefan Ciurea, Issa Khouri, Simrit Parmar, Nina Shah, Laura Worth, Gabriela Rondon, Richard Champlin, Roy B. Jones Biology of Blood and Marrow Transplantation Volume 18, Issue 11, Pages 1677-1686 (November 2012) DOI: 10.1016/j.bbmt.2012.05.011 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cytotoxicity of gemcitabine/busulfan/melphalan (Gem/Bu/Mel) on chemotherapy-resistant J45.01 cells. (A) Cell proliferation. (B) Immunoblot staining. Bu or B, busulfan; Mel or M, melphalan; Gem or G, gemcitabine, BM, bone marrow; PARP1, poly ADP-ribose polymerase; BG, busulfan/gemcitabine; MG, melphalan/gemcitabine; BMG, busulfan/melphalan/gemcitabine; Rel, relative. Biology of Blood and Marrow Transplantation 2012 18, 1677-1686DOI: (10.1016/j.bbmt.2012.05.011) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Event-free survival (EFS) and overall survival (OS) of the main histologic subsets. (A) Hodgkin lymphoma. (B) B-large cell lymphoma. Post-HDC, high-dose chemotherapy. Biology of Blood and Marrow Transplantation 2012 18, 1677-1686DOI: (10.1016/j.bbmt.2012.05.011) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions