The Taming of the NF-κB: PP4R1 Navigates while PP4c Dephosphorylates Anastasia Tikhonova, Iannis Aifantis  Immunity  Volume 37, Issue 4, Pages 594-596 (October 2012) DOI: 10.1016/j.immuni.2012.10.006 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 The PP4R1-PP4c Complex Is a Negative Regulator of NF-κB Signaling in T Cells Signaling though TCR-CD28 or TNFR1 leads to phosphorylation of IKK complex and subsequent NF-κB activation as well as PP4R1 expression. PP4R1 molecule links IKK with phosphatase PP4c resulting in partial dephosphorylation of IKK and dampening of NF-κB activity. In T cell lymphoma, absence of PP4R1 leads to inability of PP4c to associate and dephosphorylate the IKK complex, leading to untamed IKK phosphorylation and aberrant NF-κB activity. Immunity 2012 37, 594-596DOI: (10.1016/j.immuni.2012.10.006) Copyright © 2012 Elsevier Inc. Terms and Conditions