Is NF-κB2/p100 a direct activator of programmed cell death?

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Is NF-κB2/p100 a direct activator of programmed cell death? Hans Häcker, Michael Karin  Cancer Cell  Volume 2, Issue 6, Pages 431-433 (December 2002) DOI: 10.1016/S1535-6108(02)00213-1

Figure 1 NF-κB and IκB proteins Schematic representation of the NF-κB proteins RelA/p65, NF-κB2/p100, NF-κB2/p52, IκBα, and tumor-derived mutants of NF-κB2. The mutants, EB308 and LB40, were found in a cutaneous T cell lymphoma (CTLC) and a B cell chronic lymphocytic leukemia (B-CLL), respectively (Migliazza et al., 1994). DD, death domain; GRR, glycine rich region. Established (IκBα) and putative (p100) serine phosphoacceptor sites (S) are indicated. Cancer Cell 2002 2, 431-433DOI: (10.1016/S1535-6108(02)00213-1)