Angiotropic Large Cell Lymphoma (Intravascular Lymphomatosis) Occurring After Follicular Small Cleaved Cell Lymphoma David K. Carter, M.D., Kenneth P.

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Angiotropic Large Cell Lymphoma (Intravascular Lymphomatosis) Occurring After Follicular Small Cleaved Cell Lymphoma David K. Carter, M.D., Kenneth P. Batts, M.D., Piet C. De Groen, M.D., Paul J. Kurtln, M.D. Mayo Clinic Proceedings Volume 71, Issue 9, Pages 869-873 (September 1996) DOI: 10.4065/71.9.869 Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 1 Liver biopsy specimen showing angiotropic large cell lymphoma. A, Polymorphous lymphocytic infiltrate and endotheliitis in portal and sinusoidal regions. B, Some lymphocytes contain enlarged, atypical nuclei (arrows). (A and B, Hematoxylin-eosin; original magnification, x433.) Mayo Clinic Proceedings 1996 71, 869-873DOI: (10.4065/71.9.869) Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 2 Immunohistochemical appearance of hepatic angiotropic large cell lymphoma. Atypical lymphocytes (closed arrows) are positive for B-cell markers CD20 (A) and 4KB5 (B) and negative for T-ceilmarkerCD3 (C). Associated reactive T-cell lymphocytes (open arrows) stainpositively with CD3 antibodies (C). (A, B, and C, x250.) Mayo Clinic Proceedings 1996 71, 869-873DOI: (10.4065/71.9.869) Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 3 Skin biopsy specimen demonstrating angiotropic large cell lymphoma. Atypical intravascular lymphocytes and thrombi are evident. (Hematoxylin-eosin; original magnification, x250.) Mayo Clinic Proceedings 1996 71, 869-873DOI: (10.4065/71.9.869) Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions

Fig. 4 Lymph node biopsy specimens showing follicular small cleaved cell lymphoma, possible precursor to angiotropic large cell lymphoma. A, Neoplastic intrafollicular lymphocytes are immunoreactive for bel-L. (Anti-bcl-2; original magnification, x42.5.) B, Numerous small cleaved cells are present in a follicular center and adjacent mantle region. (Hematoxylin-eosin; original magnification, x240.) Mayo Clinic Proceedings 1996 71, 869-873DOI: (10.4065/71.9.869) Copyright © 1996 Mayo Foundation for Medical Education and Research Terms and Conditions