Johan W. Verjans et al. JIMG 2016;9:

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Date of download: 6/22/2016 Copyright © The American College of Cardiology. All rights reserved. From: Assessment of Coronary Plaque Progression in Coronary.

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Johan W. Verjans et al. JIMG 2016;9:1087-1095 Additional Representative Ex Vivo NIRF Imaging Examples of 2 Carotid Plaques After ICG Injection, and 2 Control Plaques Without ICG (A) From left to right, gross photograph, aligned OCT longitudinal image and 2-dimensional (2D) NIRF map (horizontal axis = 0° to 360°, vertical axis = catheter pullback distance), respectively, of 2 plaques from ICG-injected patients (+ICG) and 2 control plaques (no ICG). Pullbacks were performed with the NIRF-OCT catheter positioned within the lumen of the resected carotid artery specimens. (B) Representative simultaneously acquired and coregistered NIRF-OCT cross-sectional fusion images from ICG-injected subjects shown on the left panel of images in A. NIRF-OCT demonstrates areas of elevated ICG signal localization within each internal carotid artery plaque (left panel in B, axial white dotted line slices 36, 43, and 70 in the OCT image in A). The right panels in B show 2 axial NIRF-OCT images from saline-injected control plaques (white dotted lines 36 and 51) that reveal minimal near-infrared autofluorescence signal. The quantitative NIRF scale bars shown (0 to 250 nM) apply identically to all NIRF images from A and B. Abbreviations as in Figure 1. Johan W. Verjans et al. JIMG 2016;9:1087-1095 2016 American College of Cardiology Foundation