Fresh vs Frozen Samples and Ambient Temperature Have Little Effect on Detection of Colorectal Cancer or Adenomas by a Fecal Immunochemical Test in a Colorectal.

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Fresh vs Frozen Samples and Ambient Temperature Have Little Effect on Detection of Colorectal Cancer or Adenomas by a Fecal Immunochemical Test in a Colorectal Cancer Screening Cohort in Germany  Hongda Chen, Simone Werner, Hermann Brenner  Clinical Gastroenterology and Hepatology  Volume 15, Issue 10, Pages 1547-1556.e5 (October 2017) DOI: 10.1016/j.cgh.2016.10.018 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Flow diagram showing stool sample handling process for FIT analysis of current study. (A) FIT using frozen stool samples; (B) FIT using fresh stool samples collected in buffer-filled tubes. Clinical Gastroenterology and Hepatology 2017 15, 1547-1556.e5DOI: (10.1016/j.cgh.2016.10.018) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Comparison of ROC curves between groups providing frozen stool samples and fresh stool samples: (A) for detecting CRC, (B) for detecting advanced colorectal neoplasms (CRC or advanced adenomas), and (C) for detecting any colorectal neoplasms. FIT (fresh), FOB Gold using fresh stool samples; FIT (frozen), FOB Gold using frozen stool samples. Clinical Gastroenterology and Hepatology 2017 15, 1547-1556.e5DOI: (10.1016/j.cgh.2016.10.018) Copyright © 2017 AGA Institute Terms and Conditions

Supplementary Figure 1 Comparison of ROC curves between groups providing frozen stool samples (sensitivity analysis restricting group providing frozen samples to participants with documented adherence to requested freezing of stool samples) and fresh stool samples: (A) for detecting CRC, (B) for detecting advanced colorectal neoplasms (CRC or advanced adenomas), and (C) for detecting any colorectal neoplasms. FIT (fresh), FOB Gold using fresh stool samples; FIT (frozen), FOB Gold using frozen stool samples. Clinical Gastroenterology and Hepatology 2017 15, 1547-1556.e5DOI: (10.1016/j.cgh.2016.10.018) Copyright © 2017 AGA Institute Terms and Conditions

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