Anergic B Cells Caught in the Act Fritz Melchers  Immunity  Volume 25, Issue 6, Pages 864-867 (December 2006) DOI: 10.1016/j.immuni.2006.11.003 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Development of B-Lymphocytes in Bone Marrow and Spleen The number of cells in the various compartments (each cell represents 1.25 × 106 cells) and their status of κL chain gene rearrangements (purple cells contain secondary, “edited” κL chain gene loci), as well as estimated daily rates of turnover or transit (within purple box) are shown (see Melchers et al., 2000). G, germline configuration; V→J, rearranged. From pre-BII to naive B cells, all cells are resting and are short lived, with half-lives of 2–4 days. Expression of essential markers (+) defining the different developmental stages is shown at the bottom. Immunity 2006 25, 864-867DOI: (10.1016/j.immuni.2006.11.003) Copyright © 2006 Elsevier Inc. Terms and Conditions