Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis

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Un(MaSC)ing Stem Cell Dynamics in Mammary Branching Morphogenesis Erin Greenwood, Emma D. Wrenn, Kevin J. Cheung Developmental Cell Volume 40, Issue 4, Pages 328-330 (February 2017) DOI: 10.1016/j.devcel.2017.02.014 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Lineage-Tracing MaSCs in Mammary Branching Morphogenesis Upon puberty, TEBs proliferate and bifurcate to generate a branched, bilayered epithelial tree. (A) The authors fluorescently labeled cells randomly before puberty. Labeled MaSCs leave behind a trail of fluorescent progeny along the duct (shown in blue in inset). These MaSCs arise from TEBs. (B) MaSC cell fate is positionally biased, such that cells near the border generate daughters that contribute to ductal elongation, while cells near the tip favor self-renewal. (C) Cells mix within the TEB. MaSCs change position from border to tip and randomly segregate into one of two new branches after bifurcation. Developmental Cell 2017 40, 328-330DOI: (10.1016/j.devcel.2017.02.014) Copyright © 2017 Elsevier Inc. Terms and Conditions