Sildenafil does not prevent TRPC6 overexpression and podocyte injury in adriamycin (ADRIA)–challenged podocyte-specific PPAR-γ KO mice. Sildenafil does.

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Sildenafil does not prevent TRPC6 overexpression and podocyte injury in adriamycin (ADRIA)–challenged podocyte-specific PPAR-γ KO mice. Sildenafil does not prevent TRPC6 overexpression and podocyte injury in adriamycin (ADRIA)–challenged podocyte-specific PPAR-γ KO mice. ADRIA-induced nephropathy was induced in podocyte-specific PPAR-γ KO and wild-type mice, after which they were treated with sildenafil. Thereafter, animals were euthanized, and glomerular TRPC6 (A) protein and (B) mRNA expression was determined. In addition, protein expression of (C) desmin and (D) nephrin was measured. Protein expression is depicted as percentage of vehicle-treated mice. (E) In addition, urinary albumin-to-creatinine ratio (micrograms per micromolar) was assessed; n=3–8 animals per group. Statistical significance was determined using ANOVA followed by Bonferroni post hoc test. WT, wild type.*P<0.05 versus vehicle-injected control mice; #P<0.05 versus ADRIA–treated control mice. Ramon Sonneveld et al. JASN 2017;28:1491-1505 ©2017 by American Society of Nephrology