Early Detection of Lung Cancer by Molecular Markers in Endobronchial Epithelial-Lining Fluid Nicolas Kahn, MD, Michael Meister, PhD, Ralf Eberhardt,

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Early Detection of Lung Cancer by Molecular Markers in Endobronchial Epithelial-Lining Fluid Nicolas Kahn, MD, Michael Meister, PhD, Ralf Eberhardt, MD, Thomas Muley, PhD, Philipp A. Schnabel, MD, Christian Bender, PhD, Marc Johannes, PhD, Denise Keitel, Holger Sültmann, PhD, Felix J.F. Herth, MD, Ruprecht Kuner, PhD Journal of Thoracic Oncology Volume 7, Issue 6, Pages 1001-1008 (June 2012) DOI: 10.1097/JTO.0b013e31824fe921 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Study design of ELF biomarker discovery and validation for early NSCLC detection. ELF, epithelial lining fluid; NSCLC, non–small-cell lung cancer. Journal of Thoracic Oncology 2012 7, 1001-1008DOI: (10.1097/JTO.0b013e31824fe921) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 A, TNC gene-expression difference between ELF samples of malignant (SCC and AC) and benign diagnosis including all nodules, (B), or only nodules smaller than 25 mm in diameter. C, Distribution of individual TNC expression and nodule diameter across 41 malignant and 15 benign cases. TNC, Tenascin-C; ELF, epithelial-lining fluid. Journal of Thoracic Oncology 2012 7, 1001-1008DOI: (10.1097/JTO.0b013e31824fe921) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions