ERVmap reveals additional breast cancer-associated ERVs that correlate with cytolytic activity. ERVmap reveals additional breast cancer-associated ERVs.

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ERVmap reveals additional breast cancer-associated ERVs that correlate with cytolytic activity. ERVmap reveals additional breast cancer-associated ERVs that correlate with cytolytic activity. (A) A volcano plot depicting all 3,220 ERVs. Blue ERVs are significantly repressed and red ERVs are significantly elevated in breast cancer tissues compared with healthy controls (padj < 0.05, log2 fold-change < −1.5 or > 1.5). The top 30 significantly elevated and repressed ERVs are indicated by their names. (B) Normalized DESeq ERV read counts for previously reported TSERVs or the top 10 significantly elevated or significantly repressed ERVs identified in this report (C) are plotted as dot plots for the indicated ERVs for each sample (brca, breast cancer n = 1,246, red; normal n = 221, gray). (D) Spearman’s r correlation was calculated between the significantly elevated or repressed ERVs (padj < 0.05, log2 fold-change > 1.5 or < −1.5) and the average expression level of granzyme and perforin (CYT) for all breast cancer tissue samples. (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001). Maria Tokuyama et al. PNAS doi:10.1073/pnas.1814589115 ©2018 by National Academy of Sciences