18 November 2012 Respiratory Physiology Announcements: No lab next week. Last 2 labs on Respiration & Urinalysis. Remaining topics: Respiration and Renal Test # 3 Monday Dec 5th: CV, Resp, & part of Renal Feedback on Hemorrhage Diagrams? Chapter questions forthcoming.

1QQ 29 for 8:30 For a given bronchopulmonary segment, by what mechanism is blood flow (Q) matched to air flow (V)? What is the location and function of goblet cells?

1QQ 29 for 9:30 Describe how a person’s ventilation would be affected if he had a severely reduced amount of cartilage in the wall of his airways. Suppose a region of the lung has very little air flow (V). How is blood flow (Q) affected to that region, and by what mechanism is this accomplished? What is a treatment for obstructive sleep apnea?

Diagram on whiteboard showing heart, aorta, arterioles, 4 starling forces, and bulk flow (filtration and absorption.) Examined effects of arteriolar dilation and constriction on Pc (capillary hydrostatic pressure, TPR, and MAP.) Consider cerebral edema of Acute Mountain Sickness. View from nap site on Photographic Pass (11,400 ft)

Arterial Carbon Dioxide Hemoglobin Saturation Barometric Pressure Barometric Pressure Inspired Oxygen Alveolar Oxygen Arterial Oxygen Arterial Carbon Dioxide Hemoglobin Saturation

Figure 13.17 Who cares? Respiratory Distress Syndrome of the Newborn Law of LaPlace Surfactant reduces surface tension which reduces the mechanical effort of ventilation and prevents the collapse of smaller alveoli.

Figure 13.19 Tidal inspiration At end of normal tidal expiration

V = VT x f VA = (VT – VDS) x f Anatomic dead space = air remaining in conducting zone (typically 150 ml.) What is VA if Tidal Volume is 150 ml?

O2 uptake CO2 production

=0.8 for mixed diet 200mlCO2/min 250 ml O2/min CO2 production = Respiratory Quotient O2 uptake =0.8 for mixed diet 200mlCO2/min 250 ml O2/min = 0.8 for proteins = 0.7 for fat = 1.0 for carbohydrate C6H12O6 + 6 O2 → 6 CO2 + 6 H2O + energy