Establishment of a Zn-deficient middle-aged Sprague–Dawley rat model with prostatic Zn loss. Establishment of a Zn-deficient middle-aged Sprague–Dawley.

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Establishment of a Zn-deficient middle-aged Sprague–Dawley rat model with prostatic Zn loss. Establishment of a Zn-deficient middle-aged Sprague–Dawley rat model with prostatic Zn loss. (A) Study design: 1-mo-old male rats received a Zn-deficient or Zn-sufficient diet for 1.5, 4, or 10 mo to form six Zn-modulated age groups (n = 10–20 rats per group): Zn-deficient young-adult, adult, and middle-aged and Zn-sufficient young-adult, adult, and middle-aged. (B and C) Testis Zn content (B) and prostate Zn content (C) (measured in micrograms per gram dry weight) of young-adult, adult, and middle-aged rats on a Zn-deficient or a Zn-sufficient diet (n = 7–12 rats per group). (D) The PCNA-labeling index in middle-aged prostate is expressed as the percent of intensely stained PCNA-positive nuclei (S-phase) per ∼500 prostate epithelial nuclei evaluated in a microscope field at 200× magnification (n = 9 rats per group). (E) NF-κβ p65 DNA-binding activity of nuclear extracts from middle-aged rat prostates was measured by the TransAM NF-κβ p65 assay kit (n = 9 rats per group). (F) qPCR analysis of four selected inflammation genes, S100a8, S100a9, Cxcl5, and Ptgs2, in middle-aged rat prostates (n = 6–10 rats per group, measurements were performed in triplicate with Psmb6 as a normalizer). Data are expressed as mean ± SD. All statistics are two-sided; *P < 0.05, **P < 0.01, ***P < 0.001. Louise Y. Fong et al. PNAS 2018;115:47:E11091-E11100 ©2018 by National Academy of Sciences