Radiation Necrosis Mimicking Progressive Brain Metastasis in a Patient with Non-small Cell Lung Cancer Kadoaki Ohashi, MD, Kastuyuki Kiura, MD, PhD,

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Radiation Necrosis Mimicking Progressive Brain Metastasis in a Patient with Non-small Cell Lung Cancer Kadoaki Ohashi, MD, Kastuyuki Kiura, MD, PhD, Nagio Takigawa, MD, PhD, Shigeki Umemura, MD, Naruhito Kondo, MD, Mistuhiro Takemoto, MD, PhD, Kensuke Onoda, MD, PhD, Motoi Aoe, MD, PhD, Masahiro Tabata, MD, PhD, Mistune Tanimoto, MD, PhD Journal of Thoracic Oncology Volume 2, Issue 8, Pages 762-763 (August 2007) DOI: 10.1097/JTO.0b013e31811f3abb Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Brain metastasis of right occipital lobe 7 months after concomitant chemoradiotherapy followed by surgery (A) had regressed once 3 months after whole-brain radiation therapy and X-knife stereotactic radiotherapy (B). However, it increased in size 9 months after whole-brain radiation therapy and X-knife stereotactic radiotherapy (C) and thereafter progressed further despite the performance of cyber-knife treatment (D). Journal of Thoracic Oncology 2007 2, 762-763DOI: (10.1097/JTO.0b013e31811f3abb) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 The pathological diagnosis of the brain tumor was radiation necrosis. Fibrinoid necrosis of the blood vessel walls and reactive gliosis was observed. Journal of Thoracic Oncology 2007 2, 762-763DOI: (10.1097/JTO.0b013e31811f3abb) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions