Regional lymph nodes and distal extracranial metastases are not a reliable surrogate for actionable mutation in brain metastases. Regional lymph nodes.

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Regional lymph nodes and distal extracranial metastases are not a reliable surrogate for actionable mutation in brain metastases. Regional lymph nodes and distal extracranial metastases are not a reliable surrogate for actionable mutation in brain metastases. A–H, 8 cases for which at least one primary tumor sample, regional lymph node, and extracranial metastasis were sequenced. Phylogenetic trees and clinical histories are shown for each case as in Fig. 1. Tissue samples from extracranial metastases are depicted in green. Priscilla K. Brastianos et al. Cancer Discov 2015;5:1164-1177 ©2015 by American Association for Cancer Research