I can calculate determine inheritance through pedigrees. Objective: I can calculate determine inheritance through pedigrees. Agenda: Early Morning lab Bell Ringer Quiz Notes over Pedigrees Kahoot Review

PEDIGREES AND GENETIC COUNSELING Chapter 6 Queen Victoria and Prince Albert of the United Kingdom were cousins who had 9 children. Queen Victoria was a carrier for Hemophilia and passed is on to 4 of her children.

_______________________________________ PEDIGREE ANALYSIS _______________________________________ Chart of genetic connections in a family: 1. _________________________________ -based upon observed pattern in pedigree 2. _________________________________ -controlled breeding experiments not ethical in humans -extremely long generation time -few offspring

Pedigree Symbols

What can pedigree analysis tell us? 1. Mode of inheritance _______________________ autosomal recessive X-linked dominant ________________________ ______________________ 2. ________________________

How to determine mode of inheritance 1. Autosomal dominant -________________________ -affected child from at least 1 parent -if 1 parent is affected and other is not, about 1/2 of children affected -_____________________________________________________________________

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2. Autosomal recessive -____________________________ -< affected than unaffected individuals -both parents affected, ALL children affected -______________________________________________________________ -both sexes equally affected (autosomal & not sex-linked)

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3. X-linked dominant -_______________________________ -________________________________________________________________________ -affected female children from only 1 affected parent (X-linked recessive requires both parents be affected to produce affected daughter)

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4. X-linked recessive -_____________________________ -________________________________________________________________________ -affected fathers and non-carrier mothers never have affected children -carrier mothers and normal fathers can have affected sons, but not affected daughters -about 1/2 of sons from carrier mothers will be affected

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Hemophilia, an X-linked recessive disorder

5. Y-linked traits _________________________ Passed from father to all sons, no daughters