Kathie Alexina Wong, Mark Wass, Kay Thomas European Urology

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The Role of Protein Modelling in Predicting the Disease Severity of Cystinuria Kathie Alexina Wong, Mark Wass, Kay Thomas European Urology Volume 69, Issue 3, Pages 543-544 (March 2016) DOI: 10.1016/j.eururo.2015.10.039 Copyright © 2015 European Association of Urology Terms and Conditions

Fig. 1 Structural analysis of b(0+)AT mutations. (A) A structural model of b(0+)AT was generated and residues involved in amino acid transport were identified (cyan). Mutations (red) were mapped to analyse their potential structural and functional effects. (B) p.Gly105Arg is located at the end of the channel where amino acids are transported. (C) Some mutations (p.Arg171Trp, p.Arg333Trp) are located close to the end of the membrane and could affect membrane stability. European Urology 2016 69, 543-544DOI: (10.1016/j.eururo.2015.10.039) Copyright © 2015 European Association of Urology Terms and Conditions