Modulating tonic inhibition regulates synaptic transmission at MF-PC and PF-PC synapses. Modulating tonic inhibition regulates synaptic transmission at.

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Modulating tonic inhibition regulates synaptic transmission at MF-PC and PF-PC synapses. Modulating tonic inhibition regulates synaptic transmission at MF-PC and PF-PC synapses. (A and F) Schematic illustration for measurement of excitability in PCs by electrical stimulation (Stim.) of MF (A) and PF (F). BG, Bergmann glia; GCL, GC layer; ML, molecular layer; PCL, PC layer; Rec., recording pipette. (B, D, G, and I) Representative traces of excitatory postsynaptic potentials from WT and Best1 KO mice and GFAP-MAOB mice in −Dox and +Dox conditions (at 50-Hz stimulation). (C, E, H, and J) Summary data of firing frequency in PCs at various stimulation frequencies (unpaired t test). Error bars are SEM; *P < 0.05; **P < 0.01; ***P < 0.001. Junsung Woo et al. PNAS 2018;115:19:5004-5009 ©2018 by National Academy of Sciences