A novel detection method of non–small cell lung cancer using multiplexed bead-based serum biomarker profiling Hyun Joo Lee, MD, PhD, Young Tae Kim, MD,

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Presentation transcript:

A novel detection method of non–small cell lung cancer using multiplexed bead-based serum biomarker profiling Hyun Joo Lee, MD, PhD, Young Tae Kim, MD, PhD, Pil Je Park, PhD, Yong Sung Shin, MS, Kyung Nam Kang, MS, Yongdai Kim, PhD, Chul Woo Kim, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 143, Issue 2, Pages 421-427.e3 (February 2012) DOI: 10.1016/j.jtcvs.2011.10.046 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Schematic diagram of the modeling procedure. NSCLC, Non–small cell lung cancer. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 421-427.e3DOI: (10.1016/j.jtcvs.2011.10.046) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 The multivariate classification algorithm using the 5 highest-ranked biomarkers. A, The area under the curve was calculated for the final selected algorithm. B, The 249 samples were distinctly classified using the algorithm. Scores closer to 0 are normal and scores closer to 1 are malignant on the y axis. NSCLC, Non–small cell lung cancer; RF, Random forest; SVM, support vector machine; LDA, linear discriminant analysis; LRM, logistic regression; AUC, area under the curve. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 421-427.e3DOI: (10.1016/j.jtcvs.2011.10.046) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 The partial dependence plot using the 5 highest-ranked biomarkers. A1AT, CYFRA 21-1, IGF-1, and AFP increased likelihood of cancer with higher serum concentrations while RANTES decreased. A1AT, Alpha-1 antitrypsin; CYFRA, cytokeratin fragment; IGF, insulin-like growth factor; AFP, alpha-fetoprotein. The Journal of Thoracic and Cardiovascular Surgery 2012 143, 421-427.e3DOI: (10.1016/j.jtcvs.2011.10.046) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions