Mechanisms of HIV-associated lymphocyte apoptosis

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Mechanisms of HIV-associated lymphocyte apoptosis by Andrew D. Badley, André A. Pilon, Alan Landay, and David H. Lynch Blood Volume 96(9):2951-2964 November 1, 2000 ©2000 by American Society of Hematology

Schematic overview of the regulation of apoptosis. Andrew D. Badley et al. Blood 2000;96:2951-2964 ©2000 by American Society of Hematology

T-cell apoptosis.Mechanisms of physiologic T-cell apoptosis (top) and mechanisms of increased T-cell apoptosis associated with HIV infection (bottom). T-cell apoptosis.Mechanisms of physiologic T-cell apoptosis (top) and mechanisms of increased T-cell apoptosis associated with HIV infection (bottom). VAD refers to the pan-caspase inhibitor 2-VAD-Fmk. Andrew D. Badley et al. Blood 2000;96:2951-2964 ©2000 by American Society of Hematology

Kinetics of change in CD4 T-cell number after the initiation of protease inhibitor (PI)–based HAART. Andrew D. Badley et al. Blood 2000;96:2951-2964 ©2000 by American Society of Hematology