Volume 66, Issue 1, Pages (July 2014)

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Volume 66, Issue 1, Pages 22-29 (July 2014) Prospective Study of Diagnostic Accuracy Comparing Prostate Cancer Detection by Transrectal Ultrasound–Guided Biopsy Versus Magnetic Resonance (MR) Imaging with Subsequent MR-guided Biopsy in Men Without Previous Prostate Biopsies Morgan R. Pokorny, Maarten de Rooij, Earl Duncan, Fritz H. Schröder, Robert Parkinson, Jelle O. Barentsz, Leslie C. Thompson European Urology Volume 66, Issue 1, Pages 22-29 (July 2014) DOI: 10.1016/j.eururo.2014.03.002 Copyright © 2014 European Association of Urology Terms and Conditions

Fig. 1 Flow diagram depicting the stratified detection design of the diagnostic study showing transrectal ultrasound–guided biopsy (TRUSGB) pathway on the left and magnetic resonance–guided biopsy (MRGB) pathway on the right. Exclusion criteria: patients with prior prostate biopsy or known existing prostate cancer, 5α-reductase inhibitor therapy, contraindication to MRI (eg, pacemaker), or allergy to gadolinium contrast. ADC=apparent diffusion coefficient; DCE=dynamic contrast enhancement; DWI=diffusion-weighted imaging; mpMRI=multiparametric magnetic resonance imaging; MRI=magnetic resonance imaging; PI-RADS=Prostate Imaging Reporting and Data System; PSA=prostate-specific antigen; T2WI=T-2 weighted image; TRUS=transrectal ultrasound (guided). European Urology 2014 66, 22-29DOI: (10.1016/j.eururo.2014.03.002) Copyright © 2014 European Association of Urology Terms and Conditions