Complete Metabolic Response Is Not Uniformly Predictive of Complete Pathologic Response After Induction Therapy for Esophageal Cancer Brendon M. Stiles,

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Complete Metabolic Response Is Not Uniformly Predictive of Complete Pathologic Response After Induction Therapy for Esophageal Cancer Brendon M. Stiles, MD, Gregory Salzler, MD, Anna Jorgensen, BS, Abu Nasar, MS, Subroto Paul, MD, Paul C. Lee, MD, Jeffrey L. Port, MD, Nasser K. Altorki, MD The Annals of Thoracic Surgery Volume 96, Issue 5, Pages 1820-1825 (November 2013) DOI: 10.1016/j.athoracsur.2013.05.027 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 The sensitivity and specificity of complete metabolic response (CMR) by postinduction positron emission tomography scan for predicting complete pathologic response (CPR), n = 120 patients. The Annals of Thoracic Surgery 2013 96, 1820-1825DOI: (10.1016/j.athoracsur.2013.05.027) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Patients having complete metabolic response (CMR [n = 32]) had significantly improved overall survival compared with patients not having CMR (n = 88)—83% versus 41%, respectively (p = 0.01)—at 3 years. Among CMR patients, there was no significant difference in those with complete pathologic response (CPR [n = 13]) or those without CPR (n = 19 [dashed line]) at 3 years—73% versus 92% (p = 0.36)—although survival for those without CPR (solid line) decreased after that period. (Dotted line = standardized uptake value >0.; SUV = standardized uptake value.) The Annals of Thoracic Surgery 2013 96, 1820-1825DOI: (10.1016/j.athoracsur.2013.05.027) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions