E. Music, K. Futrega, M.R. Doran Osteoarthritis and Cartilage

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Sheep as a model for evaluating mesenchymal stem/stromal cell (MSC)-based chondral defect repair E. Music, K. Futrega, M.R. Doran Osteoarthritis and Cartilage Volume 26, Issue 6, Pages 730-740 (June 2018) DOI: 10.1016/j.joca.2018.03.006 Copyright © 2018 The Author(s) Terms and Conditions

Fig. 1 The prevalence of large animals in cartilage repair studies. (A) The number of studies found through PubMed searches of “sheep cartilage repair [text word]”, “horse cartilage repair [text word]”, “goat cartilage repair [text word]”, “pig cartilage repair [text word]”, in 5-year intervals. (B) The number of large animal cartilage repair studies that involved the use of chondrocyte, MSC, or other repair strategies between 1993 and 2017. Osteoarthritis and Cartilage 2018 26, 730-740DOI: (10.1016/j.joca.2018.03.006) Copyright © 2018 The Author(s) Terms and Conditions

Fig. 2 Anatomy of the sheep knee/stifle joint. This image was originally published by Little and colleagues as part of the OARSI Histopathology Initiative in 201021 and is reproduced here with permission. Abbreviations: LCL = lateral collateral ligament; ACL and PCL = anterior and posterior cruciate ligaments; LDE = long digital extensor; PT = popliteal tendon; MM and LM = medial and lateral meniscus; MFC and LFC = medial and lateral femoral condyle; TG = trochlear groove of distal femur. Osteoarthritis and Cartilage 2018 26, 730-740DOI: (10.1016/j.joca.2018.03.006) Copyright © 2018 The Author(s) Terms and Conditions

Fig. 3 Relative efficacy of pre-differentiated MSC for cartilage regeneration and result variability. This image was first published by Zscharnack and colleagues in 201081 and is reproduced here with permission. Top panel: representative macroscopic images of defect 6 months following treatment. Bottom panels: selected examples of best, medium, and worst results 6 months after treatment. Scale bar = 2 mm. Osteoarthritis and Cartilage 2018 26, 730-740DOI: (10.1016/j.joca.2018.03.006) Copyright © 2018 The Author(s) Terms and Conditions