Interleukin-3 (IL-3) is overexpressed by T lymphocytes in multiple myeloma patients by Nicola Giuliani, Francesca Morandi, Sara Tagliaferri, Simona Colla,

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Interleukin-3 (IL-3) is overexpressed by T lymphocytes in multiple myeloma patients by Nicola Giuliani, Francesca Morandi, Sara Tagliaferri, Simona Colla, Sabrina Bonomini, Gabriella Sammarelli, and Vittorio Rizzoli Blood Volume 107(2):841-842 January 15, 2006 ©2006 by American Society of Hematology

IL-3 expression and secretion in MM patients. IL-3 expression and secretion in MM patients. (A) Interleukin-3 (IL-3) and IL-3 receptor mRNA expression was evaluated by RT-PCR in human myeloma cell lines (RPMI-8226, XG-1, XG-6, U266, OPM2, JJN3, ARP-1, and H929) and in freshly purified MM cells as shown for 12 representative MM patients (CON+ = activated T cells). (B) IL-3 mRNA expression was checked in bone marrow mononuclear cells (BMMCs), BM stromal cells (BMSCs), and in purified BM CD14+, CD20+, and CD3+ (CD4+ and CD8+) cells obtained from MM patients and MGUS subjects as shown for 4 representative patients. (C) IL-3 levels were measured by ELISA in 48-hour supernatants of purified CD3+ cells obtained from MM patients (n = 20) and MGUS subjects (n = 10). Graph represents the mean ± SD IL-3 levels normalized to 106 cells (*P = .01). Nicola Giuliani et al. Blood 2006;107:841-842 ©2006 by American Society of Hematology