High concentrations of lactoferrin in the follicular fluid correlate with embryo quality during in vitro fertilization cycles Atsushi Yanaihara, M.D.,

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High concentrations of lactoferrin in the follicular fluid correlate with embryo quality during in vitro fertilization cycles Atsushi Yanaihara, M.D., Kaori Mitsukawa, B.Agr., Shinji Iwasaki, M.D., Katsufumi Otsuki, M.D., Toshihiro Kawamura, M.D., Takashi Okai, M.D. Fertility and Sterility Volume 87, Issue 2, Pages 279-282 (February 2007) DOI: 10.1016/j.fertnstert.2006.06.025 Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Correlation between LF level in FF and follicular size. There was no correlation between follicular size and LF level (r = 0.14; P=.217). Yanaihara. Lactoferrin in the follicular fluid. Fertil Steril 2007. Fertility and Sterility 2007 87, 279-282DOI: (10.1016/j.fertnstert.2006.06.025) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Comparison of LF level in FF and fertilization rate. Fertilized group A (mean ± SD), 500.2 ± 35.5 ng/mL; unfertilized group B, 379.7 ± 45.1 ng/mL. The mean LF level in FF of the fertilized group was significantly higher (P=.038) than that of the unfertilized group. Yanaihara. Lactoferrin in the follicular fluid. Fertil Steril 2007. Fertility and Sterility 2007 87, 279-282DOI: (10.1016/j.fertnstert.2006.06.025) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Comparison of LF level in FF and embryo quality. G1 group (mean ± SD), 337.81 ± 81.93 ng/mL; G2 group, 468.94 ± 62.04 ng/mL; G3 group, 549.1 ± 53.66 ng/mL. The LF level of G3 was significantly higher than that of G1 (P=.03). Yanaihara. Lactoferrin in the follicular fluid. Fertil Steril 2007. Fertility and Sterility 2007 87, 279-282DOI: (10.1016/j.fertnstert.2006.06.025) Copyright © 2007 American Society for Reproductive Medicine Terms and Conditions