Volume 10, Issue 1, Pages (January 2013)

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Presentation transcript:

Volume 10, Issue 1, Pages 10-15 (January 2013) Transforming growth factor-β1 level and outcome after catheter ablation for nonparoxysmal atrial fibrillation Cheng-Hsueh Wu, MD, Yu-Feng Hu, MD, Chia-Yu Chou, MD, Yenn-Jiang Lin, MD, Shih-Lin Chang, MD, Li-Wei Lo, MD, Ta-Chuan Tuan, MD, Cheng-Hung Li, MD, Tze-Fan Chao, MD, Fa-Po Chung, MD, Jo-Nan Liao, MD, Shih-Ann Chen, MD, FHRS Heart Rhythm Volume 10, Issue 1, Pages 10-15 (January 2013) DOI: 10.1016/j.hrthm.2012.09.016 Copyright © 2013 Heart Rhythm Society Terms and Conditions

Figure 1 Schematic representation of outcomes after catheter ablation for atrial fibrillation (AF). Heart Rhythm 2013 10, 10-15DOI: (10.1016/j.hrthm.2012.09.016) Copyright © 2013 Heart Rhythm Society Terms and Conditions

Figure 2 Box plot of transforming growth factor (TGF)-β1 in the different groups. Plasma TGF-β1 in the atrial fibrillation (AF) recurrence group was significantly higher than that in the nonrecurrence group among patients with nonparoxysmal AF (34.63±11.98 ng/mL vs 27.33±9.81 ng/mL; P = .026) but not in those with paroxysmal AF (32.21±10.41 ng/mL vs 34.04±12.19 ng/mL; P = .346). There was no difference of TGF-β1 levels between patients with paroxysmal AF and those with nonparoxysmal AF (33.36±11.56 ng/mL vs 32.09±11.70 ng/mL; P = .515). Heart Rhythm 2013 10, 10-15DOI: (10.1016/j.hrthm.2012.09.016) Copyright © 2013 Heart Rhythm Society Terms and Conditions

Figure 3 Atrial fibrillation–free survival by Kaplan-Meier analysis. The sinus rhythm maintenance rate was higher among patients with either transforming growth factor (TGF)-β1≤31.29 ng/mL (A) or left atrial diameter (LAD)≤43 mm (B). Heart Rhythm 2013 10, 10-15DOI: (10.1016/j.hrthm.2012.09.016) Copyright © 2013 Heart Rhythm Society Terms and Conditions

Figure 4 Outcome of catheter ablation according to the left atrial (LA) diameter (LAD) and transforming growth factor (TGF)-β1 values. Small LA was defined as LAD≤43 mm, and large LA was defined as LAD>43 mm. Low TGF was defined as TGF-β1≤31.29 ng/mL, and High TGF was defined as TGF-β1>31.29 ng/mL. Heart Rhythm 2013 10, 10-15DOI: (10.1016/j.hrthm.2012.09.016) Copyright © 2013 Heart Rhythm Society Terms and Conditions

Figure 5 Incremental prognostic value of transforming growth factor (TGF)-β1. Bar graph illustrates the improvement in global χ2 value by the addition of TGF-β1 to a Cox regression model including left atrial diameter (LAD). Heart Rhythm 2013 10, 10-15DOI: (10.1016/j.hrthm.2012.09.016) Copyright © 2013 Heart Rhythm Society Terms and Conditions