Daniel R. Croft, Michael F. Olson Cancer Cell

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Presentation transcript:

Regulating the Conversion between Rounded and Elongated Modes of Cancer Cell Movement Daniel R. Croft, Michael F. Olson Cancer Cell Volume 14, Issue 5, Pages 349-351 (November 2008) DOI: 10.1016/j.ccr.2008.10.009 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Switching between Elongated and Rounded Modes of Tumor Cell Movement Reciprocal inhibitory crosstalk between Rac and Rho GTPases determines elongated or rounded modes of movement of cancer cells. Elongated (“mesenchymal”) cell movement is driven by activation of Rac1 by a NEDD9/DOCK3 complex and consequent WAVE2-mediated actin polymerization. WAVE2 also represses actin-myosin contractility and inhibits rounded (“amoeboid”) cell movement. In contrast, RhoA and ROCK activation lead to elevated actin-myosin contractility that promotes rounded cell movement and suppresses Rac1-dependent elongated movement by activating the ARHGAP22 RacGAP. Cancer Cell 2008 14, 349-351DOI: (10.1016/j.ccr.2008.10.009) Copyright © 2008 Elsevier Inc. Terms and Conditions