SURVEY OF BIOCHEMISTRY Protein Function

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Presentation transcript:

SURVEY OF BIOCHEMISTRY Protein Function BEGIN CLASS BY REVIEWING EXAM #1

O2 Binding to Hemoglobin Hill Equation: Derive on board Y 1-Y = n log (pO2) - n log p50 log Cooperativity: binding of a ligand to one site affects the binding of other ligands to other sites. Hill Constant Cooperativity n = 1 No cooperativity (hyperbolic) n > 1 Cooperative binding n < 1 Noncooperative binding

Allosteric Interactions T state without O2 R state with O2 T -> R transition causes structural changes! See 7-1D

Bohr Effect Enhances O2 Transport As pH  O2 affinity in Hb 

Bohr Effect and O2 Transport

BPG Binds to T-State of Hb Only

Proteins in Muscle Contraction Thick filament: Myosin Thin filament: Actin Troponin Ca2+-binding protein Binds to both tropomyosin and actin Tropomyosin binds to actin

Muscle Protein Structure Myosin Complex Globular head group Long, fibrous alpha-helical tail

Force Generation in Muscle

Force Generation in Muscle

Force Generation in Muscle

Force Generation in Muscle

Force Generation in Muscle

Force Generation in Muscle

Cellular (T cells) Humoral (B cells) Immunity Viruses Fungi Parasites Foreign Tissue Humoral (B cells) Bacteria Extracellular Viruses T cells develop in thymus Antibodies develop in B cells which mature in bone marrow

Immunoglobins