Keeping ‘Trk’ of Antidepressant Actions

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Keeping ‘Trk’ of Antidepressant Actions Mounira Banasr, Ronald S. Duman Neuron Volume 59, Issue 3, Pages 349-351 (August 2008) DOI: 10.1016/j.neuron.2008.07.028 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Diagram Summarizing the Cellular Actions of BDNF-TrkB Signaling in the Neurogenic and Behavioral Responses to Antidepressants The study by Li et al. in this issue of Neuron demonstrates that conditional deletion of TrkB in GFAP-positive or Nestin-positive neural progenitor cells blocks the neurogenic and behavioral actions of antidepressant treatment and exercise. In contrast, deletion of TrkB in mature, Synapsin-positive neurons does not influence these responses. Additional studies will be required to determine if BDNF is released from the neural progenitor cells or from mature neurons. QNP, quiescent neural progenitor; ANP, amplifying neural progenitor. Neuron 2008 59, 349-351DOI: (10.1016/j.neuron.2008.07.028) Copyright © 2008 Elsevier Inc. Terms and Conditions