Epidemiology of Malaria in Latin America and the Caribbean from 1990 to 2009: Systematic Review and Meta-Analysis Ariel Bardach, MD, MSc, PhD, Agustín.

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Epidemiology of Malaria in Latin America and the Caribbean from 1990 to 2009: Systematic Review and Meta-Analysis Ariel Bardach, MD, MSc, PhD, Agustín Ciapponi, MD, MSc, Lucila Rey-Ares, MD, MSc(c), Juan Ignacio Rojas, MD, Agustina Mazzoni, MD, MSc, Demián Glujovsky, MD, MSc(c), Pilar Valanzasca, MD, MSc(c), Marina Romano, MD, Natalia Elorriaga, BSc, MSc, María Julia Dantur Juri, MD, Marcos Boulos, MD, PhD Value in Health Regional Issues Volume 8, Pages 69-79 (December 2015) DOI: 10.1016/j.vhri.2015.05.002 Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 1 Flow diagram of studies. Value in Health Regional Issues 2015 8, 69-79DOI: (10.1016/j.vhri.2015.05.002) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 2 Malaria incidence in highly endemic areas (1990–2009). Prospective studies with active case detection meta-analysis. ⁎From random-effects meta-analysis. Value in Health Regional Issues 2015 8, 69-79DOI: (10.1016/j.vhri.2015.05.002) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 3 Population-wide pooled incidence quintiles by country (per 1000 person-years) and species distribution (official Ministry of Health data, 1990–2009). This map does not reflect endemic areas within a country, but rather officially registered cases relating to the country’s total population for the years considered. Value in Health Regional Issues 2015 8, 69-79DOI: (10.1016/j.vhri.2015.05.002) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions

Fig. 4 Pooled incidence from endemic areas (API) in Latin America and Caribbean, from official sources (1990–2008). Spikes denote 95% confidence intervals. API, Annual Parasitic Index, calculated as the number of confirmed cases per population at moderate and high risk, per 1000 person-years. Value in Health Regional Issues 2015 8, 69-79DOI: (10.1016/j.vhri.2015.05.002) Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Terms and Conditions