Volume 22, Issue 6, Pages 956-958 (December 2015) Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression?  Maria Peiris-Pagès, Ubaldo E. Martinez-Outschoorn, Federica Sotgia, Michael P. Lisanti  Cell Metabolism  Volume 22, Issue 6, Pages 956-958 (December 2015) DOI: 10.1016/j.cmet.2015.11.008 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Is the Cancer Cell Metabolic Response to Oxidative Stress What Allows Metastasis? (A) Piskounova et al. (2015) provide evidence that successful metastatic cells have undergone several reversible metabolic changes that allow them to buffer oxidative stress, including upregulation in metabolic pathways that produce antioxidant power. (B) Melanoma cells that have detached from established subcutaneous tumors have higher ROS levels when they are in the bloodstream and at distant metastatic sites. Cell Metabolism 2015 22, 956-958DOI: (10.1016/j.cmet.2015.11.008) Copyright © 2015 Elsevier Inc. Terms and Conditions