Machine learning classification of OARSI-scored human articular cartilage using magnetic resonance imaging B.G. Ashinsky, C.E. Coletta, M. Bouhrara,

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Machine learning classification of OARSI-scored human articular cartilage using magnetic resonance imaging B.G. Ashinsky, C.E. Coletta, M. Bouhrara, V.A. Lukas, J.M. Boyle, D.A. Reiter, C.P. Neu, I.G. Goldberg, R.G. Spencer Osteoarthritis and Cartilage Volume 23, Issue 10, Pages 1704-1712 (October 2015) DOI: 10.1016/j.joca.2015.05.028 Copyright © 2015 Terms and Conditions

Fig. 1 Paired osteochondral samples were harvested from defined locations on the femoral condyles and used for histology and MRI measurements. Samples were obtained from medial anterior (MA), medial posterior (MP), lateral anterior (LA) and lateral posterior (LP) locations. Illustration based on Fig. 1 of Reference 9. Osteoarthritis and Cartilage 2015 23, 1704-1712DOI: (10.1016/j.joca.2015.05.028) Copyright © 2015 Terms and Conditions

Fig. 2 T2 W (2D spin-echo) of TE = 20 ms images of cartilage samples with ROIs (yellow color). The 4-well ULTEM sample holder contained six plugs per well in three wells, and DPBS in the fourth well. The ‘anterior’ and ‘left’ sample positions are indicated by the letters ‘A’ and ‘L’, respectively, while the static magnetic field, B0, is oriented into the image plane. a) Slice 1, intersecting two of the wells containing cartilage. b) Slice 2, intersecting the third cartilage-containing well and the DPBS-containing well. Osteoarthritis and Cartilage 2015 23, 1704-1712DOI: (10.1016/j.joca.2015.05.028) Copyright © 2015 Terms and Conditions

Fig. 3 Predicted OARSI score versus actual OARSI score for each sample as determined by the multiple regression for a) T1W (TI = 982 ms), b) T2W (TE = 72 ms), c) T2*W (TE = 1.44 ms), d) DWI (b = 999 s/mm2), e) MTW (Tsat = 200 ms), f) T2 (ms). R2 values for each scan type are listed on the respective graphs. The results shown are for the best-performing weighted images. Osteoarthritis and Cartilage 2015 23, 1704-1712DOI: (10.1016/j.joca.2015.05.028) Copyright © 2015 Terms and Conditions

Fig. 4 Predicted OARSI score versus actual OARSI score for each sample as determined by the multiple regression for a) T1W (TR = 7.57 ms), b) T2W (TE = 10 ms), c) T2W (TE = 20 ms), d) T2W (TE = 30 ms), e) T2W (TE = 40 ms), f) T2W (TE = 50 ms), g) T2W (TE = 60 ms), h) T2W (TE = 70 ms). R2 values for each scan type are listed on the respective graphs. The result shown are for image weightings obtained as part of the OAI. Osteoarthritis and Cartilage 2015 23, 1704-1712DOI: (10.1016/j.joca.2015.05.028) Copyright © 2015 Terms and Conditions