Apoptosis: Does stress kill?

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Apoptosis: Does stress kill? Sabina Cosulich, Paul Clarke  Current Biology  Volume 6, Issue 12, Pages 1586-1588 (December 1996) DOI: 10.1016/S0960-9822(02)70779-3

Figure 1 An outline of the apoptotic pathway in cells responding to stress stimuli or inflammatory cytokines. The early steps in the pathway are poorly understood, but recent evidence has implicated SAPKs. See text for details. Current Biology 1996 6, 1586-1588DOI: (10.1016/S0960-9822(02)70779-3)

Figure 2 Cross-talk between different MAP kinase pathways. The ERK pathway acts downstream of mitogens to induce cell proliferation, whereas the SAPK pathway induces cell death by apoptosis. See text for details. Current Biology 1996 6, 1586-1588DOI: (10.1016/S0960-9822(02)70779-3)