Homocysteine and Thrombotic Disease

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Homocysteine and Thrombotic Disease by Armando D'Angelo, and Jacob Selhub Blood Volume 90(1):1-11 July 1, 1997 ©1997 by American Society of Hematology

Homocysteine metabolic pathways. Homocysteine metabolic pathways. In the methylation pathway, homocysteine acquires a methyl group either from betaine, a reaction that occurs mainly in the liver or from 5-methyltetrahydrofolate, a reaction which occurs in all tissues and is vitamin B12–dependent. In the transsulfuration pathway homocysteine condenses with serine to form cystathionine in a reaction that is catalyzed by CBS and requires PLP. Armando D'Angelo, and Jacob Selhub Blood 1997;90:1-11 ©1997 by American Society of Hematology