Complex Patterns of Inheritance Section 10.3 & Chapter 11

Exceptions to Mendelian Genetics Summary Exceptions to Mendelian Genetics Polygenic Incomplete Dominance Co-Dominance Multiple Alleles Pleiotropy Gene linkage Sex-linked Traits OTHER Extension: Karyotype Pedigrees Patterns of inheritance Inferring genotype Non-disjunction - trisomy

Where is this happening again?

Complete Dominance

Different?

Multiple Alleles

glycoproteins = antigens A B – Codominance / multiple alleles I or i = do not make A or B A, B > i dominance A=B  Codominant Rh Factor = + or - ….another glycoprotein – present or absent Genotypes (6) = Phenotypes (4) AA, Ai = A BB Bi = B AB = AB ii = O

Universal receptor (+) Universal donor ( O -)

Poly-genic Traits

Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits. Consequently, a mutation in a pleiotropicgene may have an effect on some or all traits simultaneously. Anexample is phenylketonuria, a human disease that affects multiple systems but is caused by one gene defect. Pleiotropy: Cystic fibrosis is a good of example of pleiotropy, where a mutation in a single gene affects multiple systems in this case the lungs, pancreas, and sweat glands

Compare and Contrast

Exceptions to Mendelian Genetics Summary Exceptions to Mendelian Genetics Polygenic Incomplete Dominance Co-Dominance Multiple Alleles Pleiotropy Gene linkage Sex-linked Traits OTHER Extension: Karyotype Pedigrees Patterns of inheritance Inferring genotype Non-disjunction - trisomy

BIO SmartStarter – 11/20/15 Xb - Color Blind XB – not Color Blind 1. Make a Punnett square for the cross illustrated here. 2. What are the genotypic and phenotypic ratios (probabilities) for the offspring?