Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model Sachiko Ono, MD, PhD, Gyohei Egawa, MD,

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Margaretha A. Faber, MD, Vito Sabato, MD, Chris H

DNA vaccination against macrophage migration inhibitory factor improves atopic dermatitis in murine models Asuka Hamasaka, MD, Riichiro Abe, MD, PhD,

Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome Marita Bosticardo, PhD, Elena.

Jay A. Lieberman, MD, Faith R. Huang, MD, Hugh A

Local inflammation exacerbates cutaneous manifestations in a murine autoimmune pemphigus model Sachiko Ono, MD, Gyohei Egawa, MD, PhD, Akihiko Kitoh,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Hypertrichosis around a leg ulcer being treated with prostaglandin E1 ointment Tetsuya Honda, MD, PhD, Satoshi Koreeda, MD, PhD, Yoshiki Miyachi, MD,

Treatment of hypogammaglobulinemia in adults: A scoring system to guide decisions on immunoglobulin replacement Shradha Agarwal, MD, Charlotte Cunningham-Rundles,

Allergic sensitization can be induced via multiple physiologic routes in an adjuvant- dependent manner David Dunkin, MD, M. Cecilia Berin, PhD, Lloyd.

Maternal house dust mite exposure during pregnancy enhances severity of house dust mite–induced asthma in murine offspring Phoebe K. Richgels, MS, Amnah.

Type 2 innate lymphoid cells in induced sputum from children with severe asthma Prasad Nagakumar, MBBS, Laura Denney, PhD, Louise Fleming, MD, Andrew.

Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells Jun Young Hong, MS, J. Kelley.

Is 9 more than 2 also in allergic airway inflammation?

Intramuscular Versus Intravenous Immunoglobulin Replacement Therapy and Measurement of Immunoglobulin Levels During Immunoglobulin Replacement Therapy

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33–dependent TH2-type responses Melissa Y. Tjota, BA, Cara L. Hrusch, PhD, Kelly.

Pathergy response to skin prick testing

Differential roles for the IL-9/IL-9 receptor α-chain pathway in systemic and oral antigen–induced anaphylaxis Heather Osterfeld, BSc, Richard Ahrens,

Reduced serologic response to mumps, measles, and rubella vaccination in patients treated with intravenous immunoglobulin for Kawasaki disease Carline.

Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease Sadeep Shrestha, PhD, Howard W. Wiener,

Volume 4, Issue 5, Pages (June 2018)

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1–high T cells Jong Hoon.

Direct monitoring of basophil degranulation by using avidin-based probes Régis Joulia, PhD, Claire Mailhol, MD, Salvatore Valitutti, MD, Alain Didier,

Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis Chisa Nakashima, MD, Atsushi Otsuka, MD, PhD, Akihiko.

Critical role of IgE-dependent mast cell activation in a murine model of allergic conjunctivitis Ken Fukuda, MD, PhD, Masaharu Ohbayashi, PhD, Kei Morohoshi,

Physician needs in health informatics: Just ask the docs

The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases Hiroshi Fujishima, MD, Naoko Okada, PhD, Kenji.

Chris M. Bacon, PhD, Sarah J. Wilkinson, MRes, Gavin P

Peter M. Wolfgram, MD, David B. Allen, MD

William J. Calhoun, MD, Tmirah Haselkorn, PhD, Dave P

The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling Wataru.

Role of hyaluronan and hyaluronan-binding proteins in human asthma

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Receptor-interacting protein kinase 3 controls keratinocyte activation in a necroptosis- independent manner and promotes psoriatic dermatitis in mice

Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity Tetsuya.

Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33–basophil axis in mice Nicholas Venturelli, BS, Willem S. Lexmond, MD,

Chen Yao, BS, Sandra M. Zurawski, PhD, Elizabeth S

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Toll-like receptor 2–positive and Toll-like receptor 4–positive cells in adenoids of children exposed to passive smoking Antonio Ricci, MD, M. Antonietta.

Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice Fu-Gang Zhu, PhD, Ekambar R. Kandimalla,

Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance Lara S. Ford, MD, MPH, Katherine A. Bloom, MD,

Cephalosporin Side Chain Cross-reactivity

Switched CD21–/low B cells with an antigen-presenting phenotype in the infant thymus Christina Lundqvist, MSc, Alessandro Camponeschi, PhD, Marcella Visentini,

Xin-Zi Tang, PhD, James B. Jung, BS, Christopher D.C. Allen, PhD

Cockroach allergens: Coping with challenging complexity

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling Saeko Nakajima,

Autophagy: Nobel Prize 2016 and allergy and asthma research

Administration of Intravenous Immunoglobulin to a Patient with Hypogammaglobulinemia and Anti-IgA Antibodies Phillip Lieberman, MD, Rima Rachid, MD

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

The Janus kinase inhibitor JTE-052 improves skin barrier function through suppressing signal transducer and activator of transcription 3 signaling Wataru.

Sara Paveglio, PhD, MS, Erin Bennett, MS, Kelly L. Hawley, PhD, Adam P

Infection outcomes in patients with common variable immunodeficiency disorders: Relationship to immunoglobulin therapy over 22 years Mary Lucas, BSc,

Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice Yuri Ueharaguchi, MD, Tetsuya Honda, MD,

Machine learning, natural language programming, and electronic health records: The next step in the artificial intelligence journey? Neil Mehta, MBBS,

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis Eva Gros, MSc, Caroline Bussmann,

Long-lasting effects of sublingual immunotherapy according to its duration: A 15-year prospective study Maurizio Marogna, MD, Igino Spadolini, MD, Alessandro.

Macrolide antibiotics and asthma treatment

Prostaglandin E2–EP3 signaling suppresses skin inflammation in murine contact hypersensitivity Tetsuya Honda, MD, PhD, Toshiyuki Matsuoka, MD, PhD, Mayumi.

Asthma: The past, future, environment, and costs

Pedro Giavina-Bianchi, MD, PhD, Shih-Wen Huang, MD

PGD2 induces eotaxin-3 via PPARγ from sebocytes: A possible pathogenesis of eosinophilic pustular folliculitis Kyoko Nakahigashi, MD, Hiromi Doi, MS,

Interrupting IL-6–receptor signaling improves atopic dermatitis but associates with bacterial superinfection Alexander A. Navarini, MD, PhD, Lars E.

Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy– treated mother Sabine Flicker, PhD, Katharina Marth, MD, Heinz.

Human newborn B cells mount an interferon-α/β receptor-dependent humoral response to respiratory syncytial virus Jop Jans, MD, Matthew Pettengill, PhD,

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Intravenous immunoglobulin treatment abrogates transplacental autoantibody transfer in a murine pemphigus model Sachiko Ono, MD, PhD, Gyohei Egawa, MD, PhD, Tetsuya Honda, MD, PhD, Kenji Kabashima, MD, PhD Journal of Allergy and Clinical Immunology Volume 141, Issue 6, Pages 2273-2276.e1 (June 2018) DOI: 10.1016/j.jaci.2017.12.985 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Anti–Dsg3 antibody deposition in the fetal skin with or without IVIG treatment. A, Gating strategy of fetal keratinocytes (upper panels) and IgG1 quantification (lower panels) on keratinocytes after the injection of PBS or AK18 to pregnant mice. B, IgG1-MFI of fetuses of pregnant mice treated with IVIG or PBS. *P < .05. C, IgG1-MFI of the ear keratinocytes of adult mice treated with IVIG at 1.0 g/kg/d or PBS. FSC-A, Forward scatter-area; NS, not significant; SSC-A, side scatter-area. *P < .05. Journal of Allergy and Clinical Immunology 2018 141, 2273-2276.e1DOI: (10.1016/j.jaci.2017.12.985) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Efficacy of IVIG treatment on pemphigus manifestations. A, Hair loss in pregnant mice injected with AK23 and PBS or IVIG. B, Hematoxylin and eosin staining of the fetal back skin. Black arrows indicate intraepidermal blistering. Bars = 50 μm. C, Immunohistochemical staining of the fetal back skin (left panels) or the yolk sac placentas (right panels) of pregnant mice. Bars = 50 μm. Yellow arrows indicate epidermal AK23 deposition, green arrows indicate intrinsic IgG deposition, and red arrows indicate deposition of IVIG. D, Serum AK23 titers in fetuses. *P < .05. Journal of Allergy and Clinical Immunology 2018 141, 2273-2276.e1DOI: (10.1016/j.jaci.2017.12.985) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions