Volume 373, Issue 9666, Pages (March 2009)

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Presentation transcript:

Volume 373, Issue 9666, Pages 811-820 (March 2009) Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial Dr David Sebag-Montefiore, FRCR, Richard J Stephens, Prof Robert Steele, MD, Prof John Monson, MD, Robert Grieve, FRCR, Subhash Khanna, FRCR, Prof Phil Quirke, FRCPath, Jean Couture, MD, Catherine de Metz, MD, Arthur Sun Myint, FRCR, Eric Bessell, FRCR, Gareth Griffiths, MSc, Lindsay C Thompson, MSc, Prof Mahesh Parmar, DPhil The Lancet Volume 373, Issue 9666, Pages 811-820 (March 2009) DOI: 10.1016/S0140-6736(09)60484-0 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile CRT=chemoradiotherapy. CRM=circumferential resection margin. ITT=intention to treat. The Lancet 2009 373, 811-820DOI: (10.1016/S0140-6736(09)60484-0) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Proportion of patients with a confirmed local recurrence (A), disease-free survival (B), and overall survival (C) The Lancet 2009 373, 811-820DOI: (10.1016/S0140-6736(09)60484-0) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 3 Summary of reduction in risk of local recurrence in phase III trials that have assessed short-course preoperative radiotherapy with 5 Gy per fraction The Lancet 2009 373, 811-820DOI: (10.1016/S0140-6736(09)60484-0) Copyright © 2009 Elsevier Ltd Terms and Conditions