Decreased cell polarity and adhesion protein expression after 56Fe radiation. Decreased cell polarity and adhesion protein expression after 56Fe radiation.

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Decreased cell polarity and adhesion protein expression after 56Fe radiation. Decreased cell polarity and adhesion protein expression after 56Fe radiation. (A) Representative immunoblot images showing altered expression of factors involved in cytoskeleton (Cdc42, Rock1, Mlck), cell polarity (Par3), and cell adhesion (E-cadherin) dynamics 7 (Left) and 60 (Right) d after 56Fe irradiation relative to γ-rays. (B) Intestinal sections were stained using anti-Par3 antibody, and representative images are presented showing decreased Par3 expression after 56Fe radiation. (Scale bars, 5 μm.) (C) Intestinal sections stained for the cell adhesion marker E-cadherin, and representative images are presented showing decreased E-cadherin after 56Fe radiation. (Scale bars, 10 μm.)‏ Santosh Kumar et al. PNAS 2018;115:42:E9832-E9841 ©2018 by National Academy of Sciences