Responding to R-Spondin: Slit2 Potentiates Intestinal Regeneration

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Presentation transcript:

Responding to R-Spondin: Slit2 Potentiates Intestinal Regeneration Toby J. Phesse, Owen J. Sansom Cell Stem Cell Volume 13, Issue 5, Pages 512-514 (November 2013) DOI: 10.1016/j.stem.2013.10.006 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Treatment with rSpon1 and rSlit2 Augments Intestinal Regeneration Following treatment with 5-FU or irradiation, intestinal crypts are ablated, and large, proliferating crypts appear as the intestine attempts to regenerate. The Wnt signaling pathway is activated during regeneration and upregulates the transcription factor c-Myc, which is required for efficient proliferation. Treatment with rSpon1 and rSlit2 following 5-FU or irradiation acts to boost Wnt signaling in Lgr5+ intestinal stem cells, providing a pulse of proliferation that results in enhanced regeneration, increased organism survival, and reduced tumor formation. Cell Stem Cell 2013 13, 512-514DOI: (10.1016/j.stem.2013.10.006) Copyright © 2013 Elsevier Inc. Terms and Conditions