Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study Lujain.

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Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study Lujain H. Albenali, MD, Simon Danby, PhD, Manar Moustafa, MD, Kirsty Brown, BSc, John Chittock, BSc, Fiona Shackley, MD, Michael J. Cork, FRCP Journal of Allergy and Clinical Immunology Volume 138, Issue 6, Pages 1715-1719.e4 (December 2016) DOI: 10.1016/j.jaci.2016.05.039 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Presupplementation analysis. A, Baseline VD level comparison. Children with ADEH (black dots, n = 45) with lower VD levels compared with children with AD (gray squares, n = 45). Levels: 50-75 nmol/L (dotted lines), suboptimal; less than 50 nmol/L, deficient. B, Patients with AD (47) classified into severe AD (n = 13), moderate AD (n = 30), and mild AD (n = 4) showed significantly different VD levels. C, Baseline LL-37 levels stratified according to SCORAD were significantly different. D, VD and LL-37 correlation (P = .01). *P < .05 and **P < .01. Journal of Allergy and Clinical Immunology 2016 138, 1715-1719.e4DOI: (10.1016/j.jaci.2016.05.039) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Postsupplementation analysis (n = 47). A, SCORAD reduced 42.3% postsupplementation. B, POEM showed significant reduction (46.6%). C, LL-37 levels increased significantly from 2 ± 0.7 Log10(LL-37 pg/g) to 2.8 ± 0.8 Log10(LL-37 pg/g). D, Lesional LL-37 levels increased from 2.3 ± 0.7 Log10LL-37 pg/g to 3 ± 0.7 Log10(LL-37 pg/g). E, Nonlesional LL-37 levels increased from 2.3 ± 0.6 Log10(LL-37 pg/g) to 2.7 ± 0.8 Log10(LL-37 pg/g). Rx, Treatment. **P < .01 and ***P < .001. Journal of Allergy and Clinical Immunology 2016 138, 1715-1719.e4DOI: (10.1016/j.jaci.2016.05.039) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flowchart of study. Ninety children with AD screened for VD deficiency and classified into AD and ADEH groups on initial consultation. Of these 90, 15 were found to have normal VD levels and 75 had low VD levels. Of the 75 children with AD, 18 were lost to follow-up and 10 were excluded. Therefore, 47 children were included in the practice evaluation study. These 47 children were clinically assessed and supplemented. Journal of Allergy and Clinical Immunology 2016 138, 1715-1719.e4DOI: (10.1016/j.jaci.2016.05.039) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 The IgE level did not show a significant change from mean score 7010 ± 2370 nmol/L to 7824 ± 3221 nmol/L (P = .93; unpaired t test). Rx, Treatment. Journal of Allergy and Clinical Immunology 2016 138, 1715-1719.e4DOI: (10.1016/j.jaci.2016.05.039) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions